Comparison of the effects of Letrozole and Clomiphene Citrate towards endometrial thickness, amount and size of follicles for couples wishing to get


I Ketut Agus Sunatha

Dr.I.P.G.Wardhiana,SpOG(K)

Background: Data shows that 20-25% of infertile women have ovulation disturbances which needs medical intervention by means of ovulation induction with clomiphene citrate as the most widely used medicine. Since the year 2001 many research

had been done which supports the use of letrozole as an individual induction medicine or used in combination with exogenic FSH, and because of is advantages many researchers predict that it will be the drug of choice for the treatment of anovulation infertility.

Objective: The purpose of this study is to find the differences in effects and advantages between letrozole and clomiphene citrate for couples wishing to get pregnant.

Method: Double blind randomized design. All woman attending the fertility policlinics at Sanglah General Hospital who are eligible fo the study since December 2006 were admitted.

Sampling were done consecutively by simple randomization. Observation of endometrial thickness were done at the end of the proliferation phase and follicle development on day twelve.

Result: There were significant differences in the mean preovulation follicles between the two groups ( clomiphene ; 2,08±0,669, letrozole ; 1,50±0,52 ). There were also significant differences in the mean preovulation diameter of the follicles between he two groups ( clomiphene ; 19,56±4,23mm, letrozole ; 22,43±2,09mm ). Endometrium were thicker in the letrozole group (letrozole; 9,70±1,87mm; clomiphene citrate ; 9,14±2,24mm) but statistically there were no significant differences.

Conclusion: There were statistical differences between the use of letrozole and clomiphene citrate in the amount and size of the follicles, but not in the thickness of the endometrium.

Keywords: clomiphene citrate, endometrial thickness, follicle size, follicle diameter.

Komentar

Unknown mengatakan…
Launching Website baru Dr, I Nyoman Hariyasa Sanjaya, SpOG

WWW.HARIYASASANJAYA.COM

Bagaimana tanggapannya?

Thanks

Salam
Atx
17 Desember 2008 pukul 02.52
Posting Komentar

Postingan populer dari blog ini

MENCINTAI TANPA SYARAT???

Gambar
BISAKAH KITA MENCINTAI TANPA SYARAT Ini cerita nyata. Beliau adalah Bapak Eko Pratomo, Direktur Fortis Asset Management yang sangat terkenal di kalangan Pasar Modal dan Investment, beliau juga sangat sukses dalam memajukan industri reksadana di Indonesia. Apa yang diutarakan beliau adalah sangat benar sekali : MAMPUKAH KITA MENCINTAI TANPA SYARAT. SEBUAH PERENUNGAN Dilihat dari usianya beliau sudah tidak muda lagi, usia yang sudah senja bahkan sudah mendekati malam. Pak Suyatno, 58 tahun, kesehariannya diisi dengan merawat istrinya yang sakit. Istrinya juga sudah tua. Mereka menikah sudah lebih 32 tahun dan dikarunia 4 orang anak. Di sinilah awal cobaan menerpa. Setelah istrinya melahirkan anak ke empat tiba-tiba kakinya lumpuh dan tidak bisa digerakkan. Itu terjadi selama 2 tahun. Menginjak tahun ke tiga seluruh tubuhnya menjadi lemah bahkan terasa tidak bertulang, lidahnya pun sudah tidak bisa digerakkan lagi. Setiap hari Pak Suyatno memandikan, membersihkan kotoran, menyua...
Baca selengkapnya

Kanker Leher Rahim

         Tentu anda sudah tak asing lagi dengan istilah kanker servik (Cervical Cancer), atau kanker pada leher rahim. Benar, sesuai dengan namanya, kanker leher rahim adalah kanker yang terjadi pada servik uterus, suatu daerah pada organ reproduksi wanita yang merupakan pintu masuk ke arah rahim yang terletak antara rahim (uterus) dengan liang senggama (vagina). Kanker ini biasanya terjadi pada wanita yang telah berumur, tetapi bukti statistik menunjukan bahwa kanker leher rahim dapat juga menyerang wanita yang berumur antara 20 sampai 30 tahun.          Memang istilah "kanker" sendiri sudah pasti memberi kesan menakutkan dan menyeramkan. Laksana seorang terpidana menerima hukuman mati. Bagaimana pula dengan kanker leher rahim? Apakah juga sama menakutkannya dengan beberapa kanker lainnya? Menurut para ahli kanker, kanker leher rahim adalah salah satu jenis kanker yang paling dapat dicegah dan paling d...
Baca selengkapnya

Ectopic Pregnancy

Gambar
An ectopic pregnancy is a complication of pregnancy in which the fertilized ovum is implanted in any tissue other than the uterine wall. Most ectopic pregnancies occur in the Fallopian tube (so-called tubal pregnancies ), but implantation can also occur in the cervix , ovaries , and abdomen . The fetus produces enzymes that allow it to implant in varied types of tissues, and thus an embryo implanted elsewhere than the uterus can cause great tissue damage in its efforts to reach a sufficient supply of blood. An ectopic pregnancy is a medical emergency and if not treated properly can lead to the death of the mother. In a normal pregnancy , the fertilized egg enters the uterus and settles into the uterine lining where it has plenty of room to divide and grow. About 1% of pregnancies are in an ectopic location with implantation not occurring inside of the womb, and of these 98% occur in the Fallopian ट्यूब. In a typical ectopic pregnancy, the embryo does not reach the uterus, but...
Baca selengkapnya